Abstract
Cognitive decline is a term used to refer to the decline in neurocognitive development of a person hence the loss of language skills, memory, or executive functions. The new directions in the prevention of cognitive impairment involve the consumption of phytonutrient-dense diets. To some extent this review aims to understand the impact of resveratrol in inhibition of neuro inflammation involved in cognitive impairment. To conduct a population, intervention, comparison, outcome and time tissue search was performed with an emphasis on gathering preclinical studies and clinical research on the molecular effects that resveratrol has on neuro inflammatory pathways including insight into neuronal apoptosis and synaptic plasticity. It will be seen in the preclinical and clinical studies that due to its effect on sirtuin proteins of resveratrol reduces activity of NF-κB thus lowers inflammation response in the brain. By doing this, further worsening of neuro inflammatory markers, neuronal death as well as deterioration of the synaptic plasticity that is pivotal to the preservation of cognition is avoided. The studies done in this subject show that resveratrol has the ability to be developed for use in the management of illnesses that affect cognition. Therefore, this analysis defines the molecular mechanisms by which resveratrol perform therapeutic role to ameliorate cognitive impairment. In so doing, the development of resveratrol as a nutritional supplement or lead drug candidate can best be achieved if the drug’s role in neuro degeneration is fully understood.
Keywords: Cognitive Function, Neurodegenerative Diseases, Neuroinflammation, NF-κB Pathway, Resveratrol, Sirtuins.