Abstract
The aim of this study was to determine the role of serum HbA1c level for prediction of gestational diabetes mellitus in first trimester of pregnancy. A Prospective observational study was conducted at tertiary care center of eastern India from December 2021 to December 2022 among pregnant women attending antenatal OPD in their first trimester. Calculation of BMI, other routine investigations along with HbA1c level were done in the study population. All the recruited women were followed up with routine antenatal checkup and routinely OGTT was done at 24-28 weeks of gestational age. The prevalence of GDM in this study was 12.27%.The HbA1c value for women with GDM was 6.01 ± 0.58% on average compared to 5.12 ± 0.56% for women without GDM. The area under ROC curve for HbA1c to detect GDM was 0.894 (95% CI 0.831–0.958). HbA1c cut off value of ≥5.54% was found. This has sensitivity of 88% and specificity of 82% for diagnosing GDM. For predicting GDM, the positive predictive value was 42.1% while the negative predictive value was 98.2%. The study shows that the first trimester HbA1C value can be used as a predictor and pointer in diagnosing development of GDM in pregnant women.
Keywords: Glycated haemoglobin, Gestational diabetes mellitus, Predictor, Oral glucose tolerance test, Screening